Immunomodulation for transplantation tolerance

Immunomodulation and Disease Tolerance to Staphylococcus aureus

The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal mi...

Strategies for Antigen-Specific Immunomodulation in Experimental Organ Transplantation

Tolerance in Kidney Transplantation

Advances in immunosuppressive treatments led us to better control acute rejection and improve graft survival in organ transplantation. However, immunosuppressive drugs, due to their toxicity, are also responsible for many side effects as opportunistic infections, renal failure, cardiovascular disease and malignancy (Stegall et al, 1997; Soulillou et al, 2001; Ojo et al, 2003; Fishman et al, 200...

Tregs and transplantation tolerance.

The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. ...

Tolerance in Renal Transplantation